Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodies
Fig 7
A subset of escape mutations selected from soft-randomized library are found in natural isolates and previously-identified in vivo escape variants.
(A) Sequence analysis of the Loop D and V5 regions of our top 150 escape variants (top panel) and 5471 naturally-occurring HIV-1 isolates (bottom panel) was performed using the AnalizeAlign tool available at LANL (www.hiv.lanl.gov), and presented in logo plots. (B) Similar sequence analyses of these 150 escape variants (top panel) and the escape mutations detected in the clinical trials evaluating VRC01 or 3BNC117 is shown. Only four trials [6, 7, 11, 12], from which complete sequence information is available, are included in the analyses. For clarity, parental sequences and insertion mutations have been excluded. Clinical trial IDs, antibodies, and references are indicated for each analysis. Amino-acid numbers are based on HXB2 numbering.