Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing
Fig 5
A CEA10-derived strain is more virulent in a neutrophil-defective host.
Neutrophil-defective (mpx:rac2D57N) or control (mpx:rac2WT) larvae were infected with TBK1.1 (Af293) or TFYL49.1 (CEA10). A. CFUs were monitored, average injection CFUs: Af293 = 36, CEA10 = 32. B. Larval survival was monitored, average injection CFUs: Af293 = 35, CEA10 = 27. For all analyses, data shown are from 3 pooled replicates. For CFU analysis, data represent lsmeans ± SEM, P values calculated by ANOVA. CFU data are from 24 larvae (3 replicates, 8 larvae each) per condition per day. For survival analysis, P values were calculated by Cox proportional hazard regression analysis. See also S5 Fig.