Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific
Fig 2
TAG species profiles in pulmonary tuberculous lesions of rabbits, marmosets, and humans.
TAG species in microdissected areas of caseum and cellular regions of lesions, and uninvolved lung areas were quantified by LC-MS. In all graphs, each line represents one sample: uninvolved lung areas (light blue), cellular region (green), and caseum (orange). Marmosets: five lesional and three uninvolved lung areas (from four animals). Rabbits: six lesional and five uninvolved lung areas (from six animals). Humans: two lesional areas (one per patient) from two active tuberculosis cases, and one uninvolved lung area (from one of the two patients). One of the dominant species in this figure (TAG 52:2) was revealed by the electrospray ionization mass spectrometry analysis of human tuberculous caseum in a previous study [85].