Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus
Fig 6
RABV binding results in the downregulation of cell surface mGluR2.
Flow cytometry detected cell surface mGluR2 on RABV ERA-infected HEK293 cells (ERA), which was compared to uninfected HEK293 cells by staining with anti-mGluR2 monoclonal antibody (mGluR2) or isotype antibody control (IgG2a) at 4°C or 37°C (A). The flow cytometry results were analyzed with a one-way ANOVA (B). *, p<0.05. **, p<0.01.