A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection
Fig 5
NFATc1 and cFos cooperate to activate the Zp-V3.
(A) EBV-negative BJAB cells were transfected with the wildtype Zp-V3 luciferase vector, the Zp-V3-141A, or the Zp-V3 ZIIIA mutant promoter luciferase constructs, with or without plasmids expressing cFos and/or NFATc1 as indicated. The fold increase in luciferase activity induced by co-transfection with cFos or NFATc1 vectors for each promoter construct (relative to the vector control, set as 1) is shown. Error bars indicate standard deviation. (B) Levels of transfected NFATc1 in each condition were determined by immunoblot.