Staphylococcus aureus infection dynamics
Fig 2
NewHG S. aureus distribution at different time points during the mouse sepsis model.
Mice were infected with a 1:1:1 mixture of 3 resistance marker tagged NewHG variants and 5 mice sacrificed at each time point. (A) The proportions of each strain at each time point in the different organs in each mouse. TetR, EryR and KanR populations are blue, red and green respectively. The number in each pie chart represents the log amount of bacteria present (e.g. 10−6 CFU = 6). T.O.D: Time of Death, M.N: Mouse Number. (B) The CFU load at each time point for the organs and total CFU. Organs with CFU counts below the limit of detection (<100CFU) are represented by open circles. Error bars: mean±SD. 5 mice were sacrificed at 2hrs, 18hrs, 48hrs and 72hrs post injection of S. aureus.