Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18
Fig 3
Caspase-11 protective role in hematopoietic and radio-resistant cell types.
(A) Mice that underwent adoptive bone marrow transplant were infected with B. thailandensis (5x105 CFU) and sacrificed 48 hours p.i. to measure the organ bacterial burdens. (B) The total numbers of CD45-positive cells in bone marrow, spleen, and BALF of mice from A were calculated. One representative experiment of two is shown. Data are expressed as mean ± S.D. *p<0.05, **p<0.01, ***p<0.001 (A) Mann-Whitney U test, (B) One-way ANOVA.