Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques
Fig 2
NK cell phenotyping reveals quadrant-specific distribution and phenotypic differences among animal groups.
(A) Representative gating strategy showing identification of KLRC1±KLRC2± NK cells among NKG2AC+ NK cells as shown in Fig 1A. (B) Distribution of NK cell KLRC1±KLRC2± subpopulations in SPF and infected animals. K1+, K1+K2+, K2+ and K1-K2- correspond to KLRC1+KLRC2-, KLRC1+KLRC2+, KLRC1-KLRC2+ and KLRC1-KLRC2- populations, respectively. (C) Phenotypic markers on KLRC1±KLRC2± NK cells in SPF and infected animals. Data are show as mean ± SEM. The numbers of animals shown per group are as follows: SPF (n = 10), CMV (n = 12) and SIV (n = 8). Mann-Whitney U test was used to compare quadrant populations of different infection groups; Wilcoxon test was used to compare different quadrant populations within the same infection group; *p < 0.05, **p < 0.01, ***p < 0.0001 for panel B. Statistical data for panel C is presented in S1 Table.