< Back to Article

PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis

Fig 7

Model.

In human macrophages, M.tb induces Mcl-1 expression through PPARγ, which requires 15-LOX, cPLA₂, and the mannose receptor (MR) [4]. 15-LOX and PPARγ, through regulation of Mcl-1, contribute to M.tb’s ability to limit apoptosis and grow in human macrophages.

doi: https://doi.org/10.1371/journal.ppat.1007100.g007