Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs
Fig 2
ELISA antibody responses correlate with protection from HSV-2 genital lesions.
(A) ELISA endpoint titers are plotted from serum obtained after the third immunization. Animals are ranked from lowest to highest ELISA titer. Animal numbers are the same as assigned in Fig 1. The hatched bars represent animals with neutralizing titers ≥1:1280. (B) Cumulative lesion days per animal monitored for 60 days post infection. Animals are ordered as in A. (C) The correlation between cumulative lesion days and serum ELISA titers. (D) The correlation between neutralizing antibody titers and gD2 ELISA endpoint titers. P and rho (r) values in C and D were calculated by Spearman's correlation.