Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni
Fig 5
Principal component analysis (PCA) of ChIP enrichment for H3K4me3 (left) and H3K27me3 (right) over repetitive sequences.
All life cycle stages segregate in the PCA but miracida and Sp1 (separated by 48 hours) are very close and could only be differentiated by H3K4me3 methylation. Arrows indicate developmental direction and are there to guide the eye.