Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo
Fig 5
Neutrophils and macrophages play opposing roles during establishment of T. marneffei infection.
(A) Representative images of 52 hpf Tg(mpeg1:mCherry/mpx:EGFP) embryos injected with antisense morpholino oligonucleotides to perturb the balance of neutrophil and macrophage populations. (B) T. marneffei CFU numbers at 24 hpi corresponding to the aligned treatment groups in panels (Ai-iv), for wild-type (WT) and myeloperoxidase-deficient (mpx-/-) genotypes as shown. Data are mean±SEM for n≥3 experiments, n≥5 embryos/group/experiment.