Loss of CXCR6 coreceptor usage characterizes pathogenic lentiviruses
Fig 7
CXCR6 is expressed on natural host CD4+ T cells that are distinct from CCR5-expressing cells.
A) CCR5 (y-axis) and CXCR6 (x-axis) expression on resting SM CD4+ T cells (left) and CD8+ T cells (right). Numbers in the quadrant are the percent of CD4+ or CD8+ T cells expressing the respective combination of coreceptors. One representative animal is shown. B) Summary of CCR5 and CXCR6 single- and co-expressing cells as the percent of total CD4+ and CD8+ T cells from six SMs. Each symbol represents cells from a different individual SM. C) Resting SM PBMC were stained using antibodies to define CXCR6 expression of CD4+ memory subsets: naive (Tn: CD45RA+/ CCR7+/ CD28+/ CD95-), central memory (Tcm: CD45RA-/ CCR7+) and effector memory (Tem: CD45RA-/ CCR7-). D) Summary of CXCR6 expression of CD4+ Tn, Tcm and Tem from six SMs. Each symbol represents cells from a different individual SM. Data show individual percentages, along with mean and standard deviation.