Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana
Fig 9
Difference in glucose utilisation in WT and Δtkt cell lines.
Results of LC-MS metabolomics analysis when U-13C-glucose was used, 50% of glucose in the medium contained all carbons labelled, U-13C-glucose, and 50% was unlabelled glucose. Bars represent intensity of each respective metabolite detected. The part coloured grey is the non-labelled proportion, that labelled blue is one carbon, violet two carbons, green three carbons, orange four carbons and red six carbons labelled. (A) Metabolites of glycolysis and the PPP detected. (B) Intermediates of the TCA cycle and connected metabolites.