Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia
Fig 5
Temporal ablation of peritoneal Mϕ enhances survival of B. malayi larvae coincident with impaired tissue eosinophilia.
Cytospins of peritoneal cells with macrophages (Mϕ) indicated (A), quantification of macrophages and eosinophils (B,C,E) and recovery of B. malayi larvae (D) at indicated time points post-infection with 50 B. malayi L3 with or without prior treatment with clodronate liposomes (CL) in BALB/c WT mice or naïve controls (d0). Data from individual mice with median and interquartile range are plotted. Significant differences between groups per time point assessed by Mann-Whitney. Data is from an individual experiment or pooled from 2–3 individual experiments per time-point using groups of 4–6 mice per group / time-point.