Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia
Fig 2
In situ proliferation of macrophages with an alternatively-activated phenotype develop at the site of B. malayi infection.
Expansion of F4/80 peritoneal Mϕ (A), F4/80 peritoneal Mϕ expression levels of Ki67 (B,C), peritoneal cell (PC) arg1 expression (D) PC arginase activity (E) and F4/80 peritoneal Mϕ expression levels of RELMα (F,G) in WT BALB/c mice at indicated time points post-infection with 50 BmL3. Data from individual mice with median and interquartile range are plotted. Significant differences between naïve or infected WT groups at a given time point is assessed by Mann-Whitney or Kruskal-Wallis + Dunn’s tests (>2 groups). Data is plotted is either pooled from 2–3 individual experiments per time-point or from individual experiments with groups of 4–6 mice per group per time-point.