Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART
Fig 10
Heatmap of the global liver transcriptomic signature.
The liver transcriptome was evaluated by microarray analysis. Treatment groups (SIV+ or SIV+ cART) were compared against age-matched uninfected macaques to determine differentially expressed genes using the limma package in R/bioconductor. Co-expression analysis was performed using weighted gene coexpression network analysis (WGCNA) and heatmap packages in R/bioconductor using cutoffs of 1.5 fold change and 0.05 adjusted pvalues in at least one condition. Gene networks (modules) involved in immune response and inflammation are upregulated in SIV-infected macaques with antiviral RLR and interferon signaling highly upregulated in both adults and infants.