Regulatory T cells in retroviral infections
Fig 2
IL-2-independent expansion of Tregs during FV infection.
Depicted in brown are Treg activation events dependent on FV infection. No direct interactions between exogenous viral antigens and Tregs are required. Depicted in gray are required homeostatic signaling events for FV-induced Treg expansion. FV infection indirectly up-regulates expression of TNFR2. FV, Friend virus; IL-2, interleukin 2; mb, membrane bound; Sag, superantigen; TNFR2, tumor necrosis factor receptor 2; Treg, regulatory T cell; Vβ5, T-cell receptor variable β chain 5.