TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition
Fig 9
Restriction activities rhesus TRIM5α proteins.
HeLa cells that stably expressed the indicated HA-tagged TRIM5α proteins were infected with GFP-labeled HIV and the extent of viral replication was quantified. (A) Class I mutants. (B) Class II mutants. (C) Expression levels were quantified by immunoblotting. Experiments were repeated 6 times independently with similar results.