The 5'-poly(A) leader of poxvirus mRNA confers a translational advantage that can be achieved in cells with impaired cap-dependent translation
Fig 5
VACV post-replicative mRNAs are more efficiently translated than cellular mRNAs.
Boxwhisker plots of relative translation efficiency of VACV post-replicative mRNAs and host mRNAs at 4 and 8 hpi. Relative translation efficiency of mRNAs from uninfected HeLa cells is also shown. The bottom and top of the box indicate the first and third quartiles, respectively, with the line in the middle representing the median. Cell-M, cellular mRNAs from mock-infected cells. Cell-I, cellular mRNAs from VACV-infected cells. VACV-I, VACV mRNAs. The highest relative translation efficiency of VACV-I was off scale. ***indicates a P value < 0.001.