Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy
Fig 5
Histopathological analysis of brains from the 2nd passage of PrPres produced in dgPMCAb reactions seeded with fibrillar WT α-synuclein.
Subcallosal (a), perineuronal (b, indicated by arrows) and perivascular (c, indicated by arrows) PrP immunoreactivity as stained with anti-PrP 3F4 antibody. Ctx, cortex; cc, corpus callosum; Hp, hippocampus; LV, lateral ventricle. Scale bars: in a, c = 100 μm, b = 50 μm.