HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes
Fig 9
Distributions of epitope variant viabilities.
Top panel: The mean RE-CTL values of all variants in the virus library are plotted for each epitope. The numbers achieving thresholds of RE-CTL≥0 and RE-CTL≥-0.5 and their frequencies (over all variants adequately represented in the plasmid library) are indicated for each epitope. Variants with RE-CTL<-2 are not plotted. Bottom panel: The numbers of variants in different ranges of mean RE-CTL values are indicated.