HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes
Fig 6
Identification of single amino acid epitope variants that potentially escape from CTLs.
The net changes in RE values due to CTL selection (ΔRE = RE+CTL—RE-CTL) are displayed as color-scaled boxes for all single amino acid variants of epitopes SL9 (A), KF11 (B), and KK10 (C). The horizontal axis indicates each subtype B consensus amino acid and its immediately flanking amino acids, and the vertical axis indicates substituting amino acids. Variants that detected above threshold in the plasmid library but not in the virus library are considered non-replicating and coded by dark grey. Consensus amino acids are coded by hatched boxes.