CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo
Fig 7
CD4high HSPCs include progenitors with multi-lineage potential.
A. Representative flow plots of Sort 1 and Sort 2 bone marrow-derived HSPCs sorted using fluorescence activated cell sorting into CD4high and CD4low/- subsets. B and C. Sorted HSPCs were analyzed by methylcellulose colony formation assays. Mean ± standard deviation is indicated for counts from three blinded investigators; 2-tailed Student’s t-test (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001). CFU-E, erythroid; CFU-GM, granulocyte/macrophage and CFU-GEMM, multilineage.