LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma
Fig 7
A schematic diagram illustrating the molecular signaling pathways regulating LMP1-mediated MDSC differentiation in NPC.
LMP1 up-regulates GLUT1 expression by activating p65 and binding to GLUT1 to delay GLUT1 p62-dependent autolysosomal degradation. The increased GLUT1 expression results in more extensive glycolysis. The increase in glycolysis triggers the activation of p65 and the NLRP3 inflammasome signaling pathway, leading to the production of IL-1β, IL6 and GM-CSF from NPC cells, which promotes tumor-associated MDSC expansion in NPC microenvironments.