Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology
Fig 9
Mtb inhibits negative regulatory pathways in macrophages.
Mtb upregulates MMP-1 via the MAPK pathways, whilst concurrently inducing microRNAs that target the negative regulatory pathways that limit MMP-1 expression, leading to excessive protease production and tissue destruction.