Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology
Fig 6
Negative regulation of MMPs by MNK is more specific than PI3K/AKT/mTORC1 signalling.
Global analysis of MMP, cytokine, chemokine and growth factors secretion from macrophages at 72h by Luminex array demonstrates that MNK inhibition augments MMP-1, MMP-3 and MMP-10 secretion significantly, but conversely suppresses TH1, TH2 and chemokine secretion. Median values normalised to Mtb values of an experiment performed in triplicate are shown, and are representative of an experiment performed on two occasions.