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Microbial Community Composition Impacts Pathogen Iron Availability during Polymicrobial Infection

Fig 2

The A. actinomycetemcomitans Fur regulon.

The metabolic network differentially expressed in the Δfur mutant. Legend: green, pathways downregulated in the Δfur mutant compared to the wild type (Fur-activated); red, pathways upregulated in the Δfur mutant compared to the wild type (Fur-repressed); blue, pathways mediated by both Fur-activated and -repressed genes. Dots and lines represent compounds and reactions, respectively. PEP, phosphoenolpyruvate; ADH, alcohol dehydrogenase; Ac-CoA, acetyl-CoA; TCA, tricarboxylic acid.

Fig 2

doi: https://doi.org/10.1371/journal.ppat.1006084.g002