Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking
Fig 9
IL8- and TNF-dependent neutrophil mobilization in Mabs granuloma formation and immunoprotection.
The upper panel summarizes the contribution of the TNF/IL8 axis in the early and late response to Mabs infection leading to a controlled and chronic infection. The lower panel illustrates the detrimental effects of impaired TNF signaling that, through disruption of the IL8 production and associated defect in neutrophil mobilization, leads to impaired granuloma formation, acute infections and larval death.