The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis
Fig 5
A previously determined EBOV VP30 CTD structure clashes with the NP peptide.
Previously determined VP30 CTD structures as well as the VP30 CTD-NP peptide structures described here were structurally aligned using PyMol [27]. The EBOV NP peptide (602–614) bound to VP30 CTD is in yellow and shown as sticks. NP peptide binding is incompatible with the conformation of the VP30 CTD in 2I8B.pdb [11].