Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis
Fig 5
Importance of GlgE-mediated α-glucan synthesis for virulence of M. tuberculosis in mice.
BALB/c mice were challenged by intravenous infections with 5 × 104 colony forming units of M. tuberculosis α-glucan mutant strains (mean ± SD, n = 3 per time point). The growth of the double mutant was significantly attenuated in lung and spleen as compared to wild-type at all time-points (p < 0.05), except for the earliest 21 days post-infection time point in the lung.