A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors
Fig 5
Effects of ergot alkaloids on Sm.5HTR.
(A) Dose response relationship for various bioaminergic ligands reveals ergotamine and dihydroergotamine act as partial agonists at Sm.5HTR. (B-D) Bromocriptine (B), metergoline (C) and LSD (D) act as competitive antagonists of Sm.5HTR. (E) PZQ lacks antagonist activity at Sm.5HTR. (F) Structure-activity-relationship for various ergoline ligands at the Sm.5HTR. Data in parentheses represent pEC50 ± S.E.M or pKB ± S.E.M.