GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii
Fig 7
Infection with Toxoplasma disrupts neuronal networks and changes behavior.
A)-D) Naïve (n = 13), 6 week infected (n = 11) and ceftriaxone treated (n = 11) mice were placed in the center of an elevated plus maze and recorded for 5 minutes. B) percentage, C) frequency of time spent in the open arm of the maze and D) velocity and total distance traveled was measured between naive and infected animals. E) EEG raw traces for naïve, 6 week infected and ceftriaxone treated animals (scale bar: 1sec; dots illustrate the peak of one full rhythmic cycle). F) Approximate entropies, Student’s t-test (naïve vs infected, p<0.0001; infected vs ceftriaxone, p = 0.0057; naïve vs ceftriaxone, p = 0.0138) G) EEG power density spectrum for naïve, 4, 5 and 6-week infected and ceftriaxone treated animals. A minimum of 3 animals were used for each group and the experiments repeated twice. Asterisks represented are Bonferonni’s multiple comparison test (infected vs naive) and (ceftriaxone vs infected) H) EEG percent power calculated from power density spectral analysis in G.