GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii
Fig 6
Ceftriaxone is neuroprotective during infection with Toxoplasma.
Treatment of infected mice with ceftriaxone was conducted for one week starting at 5 weeks post-infection and compared to naïve and untreated infected mice. A minimum of 3 mice were used in each group and the experiments were repeated at least once. A) Immunohistochemistry for NeuN on 12μm thick frontal cortex frozen slices (scale bar: 80μm). Inserts: high magnification of NeuN immunohistochemistry (scale bar: 5μm) B) and C) DiI labeling of dendritic spines quantified in naïve, infected and ceftriaxone treated animals (Student’s t-test; infected vs ceftriaxone: p = 0.0004) (scale bars: 9μm).