An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism
Fig 6
Overall crystal structure of the IDV HEF protein.
(A) Ribbon representation of the trimers of ICV and IDV HEF. For ICV HEF (PDB code: 1FLC), the trimer is colored gray; For IDV HEF, one HEF protomer is colored by domain separately: fusion domain (F1, F2, F3, red), receptor domain (R, blue) and esterase domain (E1, E', E2, green) and the others are colored gray. Fusion peptides are shown in yellow. N-linked glycans are highlighted in sticks (magenta) and disulfide linkages are shown in orange. Linear order of the sequence segments in HEF colored by domains. The scissor indicates the HEF cleavage site. (B) Superposition of IDV HEF and ICV HEF subdomains are shown with RMSD values and colored by domains.