RNA-seq Brings New Insights to the Intra-Macrophage Transcriptome of Salmonella Typhimurium
Fig 7
Salmonella genes that are specifically up-regulated inside macrophages.
(A) Heatmap showing expression of 31 S. Typhimurium genes that are specifically up-regulated during infection of macrophages, compared to 20 in vitro conditions [17] (Dataset 7 in S1 Table) (Materials and Methods). The heatmap colours represent the absolute expression levels (log10 TPM values) based on the colour bar below. (B) The relative expression level of each gene is the fold-change of macrophage versus [expression in the in vitro condition where the gene in maximally expressed], based on the colour bar to the right. (C) The SPI13 operon (lgl [37] and ripABC [25], or STM3117 and STM3118-STM3120, respectively) is highly induced within macrophages.