TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus
Fig 2
TRIM21 promotes two waves of innate immune signaling in response to antibody-opsonized virus.
(A) TNFα mRNA levels in MEF cells following challenge with AdV or AdV pre-incubated with human serum IgG (AdV+IgG). (B) TNFα mRNA levels in MEF cells 4 hours post challenge with PBS, IgG, AdV, AdV+IgG, p(I:C). (C) As (B) except 8 hours. (D) TNFα mRNA levels in MEF cells following challenge with HRV or HRV+IgG. (E) TNFα mRNA levels in MEF cells after HRV or HRV+IgG. (F) TNFα mRNA levels in MEF cells challenged with DNA or AdV+IgG at 4 hours and 8 hours. Media either continuously exchanged (Wash, gray striped) or cells incubated as previously (Control, black).