Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B
Fig 5
Differential induction of whole blood gene expression by low dose and high dose wIFN-α.
qRT-PCR data for (a) ISGs and (b) TH1-type cytokine genes expressed as fold-change relative to week 0 pre-dose (pre-treatment baseline). The bar height indicates the mean maximal fold-change for each group, and the errors bars represent the standard error of the mean. Placebo: maximal induction at 6 hours post-dose at weeks 0, 1, 3, 7, 11 and 15. 20 μg: maximal induction at 6 hours post-dose at weeks 0, 1 and 3. 100 μg: maximal induction at 6 hours post-dose at weeks 7, 11 and 15. Animals from the wIFN-α treatment group were only included if data from all relevant time-points was available. Statistical significance was calculated with log-transformed values by one-way ANOVA with Tukey's multiple comparison correction.