Intracellular Uropathogenic E. coli Exploits Host Rab35 for Iron Acquisition and Survival within Urinary Bladder Cells
Fig 7
Schematic representation of how the presence or absence of Rab35 affects the fate of UPEC survival within UCV.
In Rab35-sufficient conditions, UCV fuses or acquires the markers for early/recycling endosomes (Rab35, TfR) and late endosomes (LAMP1), acquires iron and prevents the fusion of UCV with late lysosomes leading to UPEC survival. In the Rab35-deficient conditions, the UCV is unable to acquire Rab35/TfR and iron and subsequently UPEC gets killed by fusion of UCV with late lysosomes.