Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease
Fig 2
Chemogenomic profiling in S. cerevisiae suggests cytochrome b as the target of GNF7686 in yeast.
A) HIP profile of GNF7686. B-D) Alignment of the HIP profile of GNF7686 with profile of cytochrome b inhibitor strobilurin (B), F-type ATPase inhibitor venturicidin (C), and microtubule-binding fungicide benomyl (D).