The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model
Fig 5
Schematic illustration of the detection of non-PB and PB variants of EV71.
Virus detection and genetic variants of EV71 from clinical samples (Table 1) and postmortem tissue samples (Table 2) are summarized. Positive samples by molecular detection (++ or + in Tables 1 and 2) for EV71 are indicated and classified into PB (VP1-145G) or non-PB (VP1-145E) variants according to the amino acid residue at VP1-145 from the partial VP1 sequences determined by direct RT-PCR from samples. PB and non-PB variants are shaded in orange and blue, respectively.