The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model
Fig 2
Time-course of clinical observations.
Four monkeys (#5061, #5132, #5133, and #5137) were inoculated with the EV71-02363-KE (non-PB) strain and four monkeys (#5131, #5134, #5135, and #5136) were inoculated with the EV71-02363-EG (PB) strain. One monkey (#5061) exhibited decreased limb grip strength for 5–10 days postinfection (p.i.), without apparent paralysis, tremor, or ataxia.