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Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

Fig 5

Thermal unfolding curves of KPC variants as measured by circular dichroism at 222 nm.

The identity of each variant is indicated by the symbol shape and color shown in the inset.

doi: https://doi.org/10.1371/journal.ppat.1004949.g005