Intracellular Growth Is Dependent on Tyrosine Catabolism in the Dimorphic Fungal Pathogen Penicillium marneffei
Fig 5
Genes of the tyrosine catabolic cluster are required for hyphal growth on tyrosine and phenylalanine as a nitrogen or carbon source at 25°C.
Growth of the wildtype, ΔwA, ΔhpdA, ΔhmgA, ΔhmgX, ΔmaiA, ΔhmgR, and ΔareA strains on carbon and nitrogen free medium (C and N free), on ammonium as the sole nitrogen source (gluc NH4), on phenylalanine as the sole nitrogen source (gluc phe), on phenylalanine as the sole carbon source (phe NH4), on tyrosine as the sole nitrogen source (gluc tyr) or on tyrosine as the sole carbon source (tyr NH4) after 14 days at 25°C.