Yersinia pestis Activates Both IL-1β and IL-1 Receptor Antagonist to Modulate Lung Inflammation during Pneumonic Plague
Fig 5
IL-1RA contributes to control of Y. pestis replication and pathology in the lung.
A. Histology of fixed H&E stained lung sections from mice at 24 hpi with Y. pestis, +/- IL-1RA nAb. Small foci of inflammation indicated by arrows. B. Inflammation from histopathology sections was quantified as described in Methods. C. Bacterial burdens were assessed from mice 24 hpi with Y. pestis, +/- IL-1RA nAb. D. Cytokine analysis from lysates of homogenized lungs of mice infected with Y. pestis +/- IL-1RA nAb for 24 hrs was perfomed by ELISA (BD Pharmingen). * p<0.05, ** p<0.001.