Yersinia pestis Activates Both IL-1β and IL-1 Receptor Antagonist to Modulate Lung Inflammation during Pneumonic Plague
Fig 2
IL-1β/IL-18 cytokine activation contributes to pathology of pneumonic plague.
A. A survival analysis was performed comparing wild-type (n = 8), Caspase 1-/- (n = 15) and Il-1β/IL-18-/-(n = 12) mice (on C57BL/6 background) after LD100 infection (104 CFU/mouse) of Y. pestis strain CO92. B. Total lung burden (CFU/lung) at 48 hpi after LD100 infection with Y. pestis strain CO92. C. fixed H&E stained lung sections from mice at 48 hpi. D. Inflammation from histopathology sections was quantified as described in Methods. * p<0.05, ** p<0.001.