Viral and Cellular Proteins Containing FGDF Motifs Bind G3BP to Block Stress Granule Formation
Fig 5
Molecular model of G3BP/FGDF interaction.
(A) G3BP-NTF2 (PDB ID: 4FCM) with modelled peptide LTFGDFDE (yellow sticks). The protein is shown as the surface colored according to the electrostatic potential (red: acidic, blue: basic). (B) Details of the interaction of the peptide with G3BP-NTF2. G3BP-NTF2 is shown in the cartoon representation. The N-terminal 11 residues as well as several residues lining the peptide-binding groove are displayed as grey sticks. The LTFGDFDE peptide is displayed as yellow sticks, peptide amino acid residues are labeled in red and in bold font. G3BP-1 residues mentioned in the text are labeled in black.