Specificity and Dynamics of Effector and Memory CD8 T Cell Responses in Human Tick-Borne Encephalitis Virus Infection
Figure 5
Transcription factor profile of TBEV-specific cells.
(A) Plots are gated on total CD8 T cells (black background) or TBEV-specific (NS3 ILL) CD8 T cells (green dots). (B) Bar plots show the median and 10–90th percentiles of each marker in ILL+ specific cells from five donors. (C) Bar plots show the median and 10–90th percentiles of each marker in total CD8 T cells from five donors (D) Bar chart represents subset distribution of T-bet, Eomes and Ki67 in TBEV-ILL-specific cells. (E) Bar chart represents subset distribution of T-bet, Eomes and Ki67 in total CD8 T cells. (F) Median and 10–90th percentiles of Eomes+Ki67+T-bet+ total CD8 T cell subset at day 7, 21 or 90 after hospitalization in infected subjects (n = 10) together with healthy controls (n = 16). (G) Median and 10–90th percentiles of granzyme B and perforin in Eomes+ and Eomes− total CD8 T cell subsets at day 7 after hospitalization. Statistical analysis was performed by using non-parametric repeated measures ANOVA test or Mann-Whitney test. *, p < 0.05; **, p < 0.01; ***, p < 0.001.