Specificity and Dynamics of Effector and Memory CD8 T Cell Responses in Human Tick-Borne Encephalitis Virus Infection
Figure 2
Transcriptional profile of activated CD8 T cells.
(A) Flow plots show Helios, T-bet and Eomes stainings in CD8 T cells from one representative donor. (B) Bar plots show the 10–90th percentiles of T-bet, Eomes and Helios expression in the CD38 and Ki67 co-expressing CD8 T cell subset at day 7 after hospitalization (n = 10), and at day 7 after hospitalization in non-activated cells or in non-activated healthy controls (n = 16). (C) Heat map represents subset distribution of Eomes and T-bet within the CD38 and Ki67 co-expressing CD8 T cells (n = 10). Statistical analysis was performed using the Mann-Whitney test. *, p < 0.05; **, p < 0.01; ***, p < 0.001.