A Rho GDP Dissociation Inhibitor Produced by Apoptotic T-Cells Inhibits Growth of Mycobacterium tuberculosis
Figure 5
Apoptotic Foxp3+ cells are the source for D4GDI.
(A) Expression of D4GDI by apoptotic Foxp3+ cells. CD4+ cells and autologous monocytes from 6 persons with LTBI were cultured with γ-irradiated H37Rv. After 4 days, CD4+CD25+Foxp3+, CD4+CD25+Foxp3- and CD4+CD25-Foxp3- cells that expressed annexinV and/or D4GDI were identified by flow cytometry. Mean values, p values and SEs are shown. (B) A representative flow cytometry plot is shown.